Edited by: Karen Young Kreeger
S.F. Dowdy, P.W. Hinds, K. Louie, S.I. Reed, A. Arnold, R.A. Weinburg, "Physical interaction of the retinoblastoma protein with human D cyclins," Cell, 73:499-511, 1993. (Cited in 150 publications through February 1995)
M.E. Ewen, H.K. Sluss, C.J. Sherr, H. Matsushime, J. Kato, D.M. Livingston, "Functional interactions of the retinoblastoma protein with mammalian D-type cyclins," Cell, 73:487-97, 1993. (Cited in 163 publications through February 1995)
Comments by Steven F. Dowdy, Washington University School of Medicine and Howard Hughes Medical Institute; and Mark E. Ewen, Dana Farber Cancer Institute and Harvard Medical School
The two articles describe the physical interactions between the retinoblastoma protein and D cyclins, a basic discovery in cell biology that has ramifications for the study of cancer.
Both types of proteins are important in regulating the cell cycle, the many-step process of cellular division and replication. The retinoblastoma protein--called pRb for short--is also ...
