Cell Biology/ Signal Transduction

M. Muller, J. Briscoe, C. Laxton, D. Guschin, A. Ziemiecki, O. Silvennoinen, A.G. Harpur, G. Barblerl, B.A. Witthuhn, C. Schindler, S. Pellegrini, A.F. Wilks, J.N. Ihle, G. Stark, I.M. Kerr, "The protein tyrosine kinase JAK1 complements defects in interferon-a/b and g signal transduction," Nature, 366:129-35, 1993. (Cited in more than 150 publications through September 1995) Z. Zhong, Z.L. Wen, J.E. Darnell, Jr., "STAT3-a STAT family member activated by tyrosine phosphorylation in response to

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Z. Zhong, Z.L. Wen, J.E. Darnell, Jr., "STAT3-a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6," Science, 264:95-8, 1994. (Cited in about 100 publications through September 1995)

Comments by James E. Darnell, Jr., Rockefeller University; George R. Stark, Cleveland Clinic Foundation Research Institute; and Zhong Zhong, Columbia University College of Physicians and Surgeons

These papers are two among a host of highly cited reports on the subject of signal transduction involving two protein families-the JAKs and STATs-to emerge from the laboratories of James E. Darnell, Jr. at Rockefeller University, Ian M. Kerr of the Imperial Cancer Research Fund in London, and George R. Stark of the Cleveland Clinic Foundation Research Institute. They represent two independent approaches-genetic and biochemical-to studying various aspects of the signaling system.

'JAKS' OF ALL TRADES: James E. Darnell, left and Zhong Zhong discovered the ubiquity of the JAK-STAT pathway ...

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