Following are both Science Watch reports, along with their respective lists, reprinted here with the permission of the newsletter and ISI. For more information on the citation databases and papers discussed in the articles, contact Christopher King, editor of Science Watch, ISI, 3501 Market St., Philadelphia, Pa. 19104; (800) 523-1850, Ext. 1341. Fax: (215) 387-1266. E-mail: cking@isinet.com. World Wide Web: http://www.isinet.com.
Alzheimer's is associated with a wide range of pathologies, but two features are of crucial importance: innumerable extracellular plaques of the small amyloid-ß protein and neurofibrillar tangles. These are intracellular bundles of abnormal filaments of highly phosphorylated forms of the protein tau, which is normally associated with microtubules. Hitherto, genes have been discovered that could have a role in both.
On chromosome 19 a mutant form of the apolipoprotein E gene, known as e4, is associated with an increased likelihood of AD that first manifests when the patient is ...
