Each issue, The Scientist publishes a review, like the one above, that examines related papers in a single field. We also publish a selection of comments on interesting recent papers from the Faculty of 1000's output. For more information visit www.facultyof1000.com.
The nucleolus has long been known to play a role in the transcription and processing of large ribosomal RNAs and ribosome assembly. However, according to Lucio Comai, assistant professor of molecular microbiology and immunology at the University of Southern California, other nucleolar functions are being revealed, including regulatory sequestering of cell cycle proteins.
To shed light on these other possible nucleolar functions, researchers in the labs of Angus Lamond, professor at the University of Dundee and Matthias Mann, professor at the University of Southern Denmark, biochemically isolated nucleolar proteins, and then used a combination of mass spectrometry and sequence database searches to identify 271 nucleolar proteins.1 "So far, this ...
