The Faculty of 1000 is a Web-based literature awareness tool published by BioMed Central. It provides a continuously updated insider's guide to the most important peer-reviewed papers within a range of research fields, based on the recommendations of a faculty of more than 1,400 leading researchers.

Each issue, The Scientist publishes a review, like the one above, that examines related papers in a single field. We also publish a selection of comments on interesting recent papers from the Faculty of 1000's output. For more information visit

Using cutting-edge technology and creative adaptations of older techniques, two groups recently uncovered new dynamics and complexity in the nucleolus—a nuclear organelle that organizes around the genes that encode ribosomal RNA during each cell cycle. Their work provides a compelling framework for future research on the function of nucleolar proteins, as well as large-scale proteomics in general.

The nucleolus has long been...

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