April 2002

For some children, science is as palatable as brussels sprouts. To elevate the topic in the minds of primary and secondary students, the Franklin Institute of Philadelphia and the Science Museum of London have collaborated to publish an online science gallery entitled "Pieces of Science," www.fi.edu/pieces. The 16 featured objects, from a beginner's guide to genetic engineering to the story of the mold Sir Alexander Fleming discovered and transformed into penicillin has its own its Web page, com

Ben A. Hitt is living proof that you can leave biomedical research without saying goodbye forever. More than 20 years since turning out the lights in the lab for what he thought was the last time, Hitt is not only back, he's in demand. Now chief scientist for Correlogic Systems, in Bethesda, Md., his phone hasn't stopped ringing since Feb. 16, when a paper in The Lancet1 announced that Proteome Quest, the pattern-recognition software he created, had identified a pattern among five serum proteins

The once white-hot investment climate for proteomics has cooled, sending companies scrambling to recast themselves. Biotech analysts and investors say interest in proteomics companies peaked about a year ago with a rash of them competing in the technology and database sectors. In Europe, proteomics companies have also experienced a downturn, with biotech stocks falling 40% from their peak in 2000. Developing a new generation of technology and digitally mapping the proteome was, relatively speaki

If mapping the entire human proteome isn't challenge enough, consider this: The Human Proteome Organization, created this past year, aims to coordinate the efforts of the many public and private groups moving into the proteomic field.1 HUPO president Samir Hanash hopes an April 29 meeting at the National Institutes of Health will solidify plans and collaborations to characterize all blood serum proteins, create a library of antibodies to every human protein, and put the data collected in a user

A study group appointed by the 5,200-member Society of Toxicology, based in Reston, Va., recently issued a draft position paper affirming the safety of foods made from genetically modified (GM) crops. If approved by the society's full membership and council, the report should make biotech enthusiasts happy: It supports key principles governing federal regulatory policy and nixes pet arguments made by the technology's critics. The draft report was posted on a 'members only' page of the society'

Amorphophallus titanum—the botanical mouthful is the Latin name for Titan arum, a Sumatran cousin of the common philodendron. Unlike the diminutive houseplant, Titan lives up to its label by producing giant leaves more than 20 feet long and 50 feet around. Only one leaf appears each growing season, springing from an underground storage organ, or tuber, that can weigh more than 100 pounds. The tropical Titan doesn't do sex very often—just a few times in its 40-year life span—but

Just three weeks before E.T. flew back into movie theaters to celebrate his 20th anniversary, a group of interdisciplinary scientists, science fiction authors, teachers, and others interested in the real quest for extraterrestrial life assembled in the Silicon Valley for the 19th annual CONTACT conference (www.cabrillo.cc.ca.us/contact). This year, as part of the conference, 12 scientists from various fields coalesced around the theme "Is life rife in the Universe?" in a day-long symposium at th

The Ames, Iowa-based Council for Agricultural Science and Technology recently issued a report on the dangers posed by invasive pests to agriculture, public health, and natural ecosystems. A six-member task force co-chaired by Don Huber of Purdue University in West Lafayette, Ind., and Martin Hugh-Jones of Louisiana State University in Baton Rouge, documented research on the problem and recommended how to alleviate it. "If a pest can enter the United States, over time, it will find a way here, s

The idea of vaccinating Alzheimer Disease (AD) patients against Ab has been backwards from the start.1 AD is probably already an immune response against Ab, hence the vaccine would worsen AD, not cure it. Evidence that this is indeed the case, comes from the idea that microglia are activated by the treatment. This was, in fact, the very first evidence suggesting an immune cause of AD.2 Astrocytes may also be involved in the response. The problem is that immunologists, for the past 15 years, hav

I and my group heartily agree with Edward L. McNeil1 about the need to search for infectious agents in idiopathic diseases, although there is often the problem of cause and effect: Detection of an infectious agent in the diseased tissue does not necessarily mean that it is involved in the pathogenesis of the disease. However, in Alzheimer disease (AD) an infectious agent has indeed been sought—and found, and implicated directly as a cause. Using polymerase chain reaction (and taking extrem