Toward a Global Proteome

If mapping the entire human proteome isn't challenge enough, consider this: The Human Proteome Organization, created this past year, aims to coordinate the efforts of the many public and private groups moving into the proteomic field.1 HUPO president Samir Hanash hopes an April 29 meeting at the National Institutes of Health will solidify plans and collaborations to characterize all blood serum proteins, create a library of antibodies to every human protein, and put the data collected in a user

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"We don't want to say that we will do the whole proteome in the next 18 months," says Hanash, a professor of pediatrics and communicable diseases at the University of Michigan. "That's impossible. But at the same time, it's not true that there's nothing you can do."

Industry groups have lofty aspirations as well as proprietary concerns. Myriad Proteomics proclaimed last year it would complete a map of every human protein-protein interaction by 2004.2 Information-based biotechs are increasingly steering into pharmaceutical development making it imperative for them to patent newly generated data, a practice that might not mesh with the HUPO vision.

Some HUPO members say they hope the organization will foster collaboration and education programs and set standards, but not oversee or fund projects. "We don't want to come across as the organization that's driving proteomics and you're either in or you're out," says Emanuel F. Petricoin, codirector of ...

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