DNA Repair

Edited by: Karen Young Kreeger T. Blunt, N.J. Finnie, G.E. Taccioli, G.C.M. Smith, J. Demengeot, T.M. Gottlieb, R. Mizuta, A.J. Varghese, F.W. Alt, P.A. Jeggo, S.P. Jackson, "Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine SCID mutation," Cell, 80:813-23, 1995. (Cited in almost 120 publications as of December 1996) Comments by Frederick W. Alt, Howard Hughes Medical Institute, Children's Hospital, Boston, and Harv

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Edited by: Karen Young Kreeger
T. Blunt, N.J. Finnie, G.E. Taccioli, G.C.M. Smith, J. Demengeot, T.M. Gottlieb, R. Mizuta, A.J. Varghese, F.W. Alt, P.A. Jeggo, S.P. Jackson, "Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine SCID mutation," Cell, 80:813-23, 1995. (Cited in almost 120 publications as of December 1996)

Comments by Frederick W. Alt, Howard Hughes Medical Institute, Children's Hospital, Boston, and Harvard Medical School; and Guillermo E. Taccioli, Boston University School of Medicine

Photo: Barbara Stunir

QUICK FIX: From left, Frederick Alt and Guillermo Taccioli and their colleagues identified DNA-dependent kinase as a key enzyme involved in DNA repair.

The way that DNA repairs itself recently has been the object of study in many labs. One collaborative effort among researchers in the United Kingdom, Canada, and the United States has shed light on an enzyme that catalyzes this process.

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