For this article, Eugene Russo interviewed Ellis R. Levin, chief of endocrinology and metabolism at the Long Beach Veterans Affairs Medical Center and vice chairman for research in the department of medicine at the University of California, Irvine. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.
M. Razandi, A. Pedram, G.L. Greene, E.R. Levin, "Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: Studies of ER alpha and ER beta expressed in Chinese hamster ovary cells," Molecular Endocrinology, 13:307-19, February 1999. (Cited in 110 papers)

For years, endocrinologists believed that the actions of estrogen and other steroids were confined to the cell's nucleus. By presenting evidence for a plasma membrane estrogen receptor (ER), this paper made the rather unorthodox claim that estrogen also...

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