Face to Face with the Emotional Brain

By Ahmad R. Hariri & Paul J. Whalen Face to Face with the Emotional Brain Amygdala responses to the facial signals of others predict both normal and abnormal emotional states. An understanding of the brain chemistry underlying these responses will lead to new strategies for treating and predicting psychopathology. Ikon Images / Corbis One of our favorite scientific studies of the past few years is a laboratory assessment of how people react to strangers,

Written byAhmad R. Hariri and Paul J. Whalen
| 11 min read

Register for free to listen to this article
Listen with Speechify
0:00
11:00
Share

One of our favorite scientific studies of the past few years is a laboratory assessment of how people react to strangers, conducted by Alex Todorov and colleagues at Princeton.1 They presented subjects with pictures of faces—many faces—that they had never seen before. All of the faces were intended to have no discernable expression, that is, they wore neutral expressions. The subjects were asked to rate how trustworthy they thought each face was based on a gut reaction. Naturally, each subject thought that some of the faces were more trustworthy-looking, some were less trustworthy-looking, and some were neutral. At the same time, the response of each subject’s amygdala—a deep brain structure—was measured using functional magnetic resonance imaging (fMRI).

The measured responses showed some relationship with the judgments the subjects made about the faces. Specifically, the amygdala responses were greatest to faces judged to be the most untrustworthy. As cool as that ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

Published In

Share
December digest cover image of a wooden sculpture comprised of multiple wooden neurons that form a seahorse.
December 2025, Issue 1

Wooden Neurons: An Artistic Vision of the Brain

A neurobiologist, who loves the morphology of cells, turns these shapes into works of art made from wood.

View this Issue
Stacks of cell culture dishes, plates, and flasks with pink cell culture medium on a white background.

Driving Innovation with Cell Culture Essentials

Merck
Stacks of cell culture dishes, plates, and flasks with pink cell culture medium on a white background.

Driving Innovation with Cell Culture Essentials

MilliporeSigma purple logo
Human iPSC-derived Models for Brain Disease Research

Human iPSC-derived Models for Neurodegenerative Disease Research

Fujifilm
Abstract wireframe sphere with colorful dots and connecting lines representing the complex cellular and molecular interactions within the tumor microenvironment.

Exploring the Inflammatory Tumor Microenvironment 

Cellecta logo

Products

brandtech logo

BRANDTECH® Scientific Announces Strategic Partnership with Copia Scientific to Strengthen Sales and Service of the BRAND® Liquid Handling Station (LHS) 

Top Innovations 2026 Contest Image

Enter Our 2026 Top Innovations Contest

Biotium Logo

Biotium Expands Tyramide Signal Amplification Portfolio with Brighter and More Stable Dyes for Enhanced Spatial Imaging

Labvantage Logo

LabVantage Solutions Awarded $22.3 Million U.S Customs and Border Protection Contract to Deliver Next-Generation Forensic LIMS