For Tomorrow's Infantry: SS-220, a Gunsight-friendly Insect Repellent

Since 1948, military men and women have smeared on DEET, otherwise known as N,N-diethyl-3-methylbenzamide, to repel the itchy, the deadly, and the otherwise annoying. DEET is effective but unloved--it literally melts plastic--and the US military has been working for some time to find a replacement. The newcomer is called SS-220. At the army's Aberbeen Proving Ground in Maryland, SS-220 has passed toxicity tests for short-duration exposure. Lab tests with human volunteers and mosquitoes, Anop

Written byTom Hollon
| 6 min read

Register for free to listen to this article
Listen with Speechify
0:00
6:00
Share

Since 1948, military men and women have smeared on DEET, otherwise known as N,N-diethyl-3-methylbenzamide, to repel the itchy, the deadly, and the otherwise annoying. DEET is effective but unloved--it literally melts plastic--and the US military has been working for some time to find a replacement. The newcomer is called SS-220.

At the army's Aberbeen Proving Ground in Maryland, SS-220 has passed toxicity tests for short-duration exposure. Lab tests with human volunteers and mosquitoes, Anopheles stephensi (a malaria carrier) and Aedes aegypti (a yellow fever carrier) confirm that SS-220 repels as well as DEET.1 Col. Daniel Strickman of the Walter Reed Army Institute of Research, in Washington, DC, who has access to one of the few sand fly colonies in the country, says that SS-220 equals DEET in repelling the sand flies, which transmit leishmaniasis.

A company now negotiating to develop SS-220 "has done its homework" says Jerome Klun, research entomologist ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

Published In

Share
February 2026

A Stubborn Gene, a Failed Experiment, and a New Path

When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.

View this Issue
Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter Logo
Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

bioxcell

Products

Sino Biological Logo

Sino Biological Pioneers Life Sciences Innovation with High-Quality Bioreagents on Inside Business Today with Bill and Guiliana Rancic

Sino Biological Logo

Sino Biological Expands Research Reagent Portfolio to Support Global Nipah Virus Vaccine and Diagnostic Development

Beckman Coulter

Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

Refeyn logo

Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies