 CLEVER METHOD: Roger K. Wolff of Progenitor Inc. led a research team that used linkage disequilibrium mapping to locate the gene for hereditary hemochromatosis.
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J.N. Feder, A. Gnirke, W. Thomas, Z. Tsuchihashi, D.A. Ruddy, A. Basava, F. Dormishian, R. Domingo, M.C. Ellis, A. Fullan, L.M. Hinton, N.L. Jones, B.E. Kimmel, G.S. Kronmal, P. Lauer, V.K. Lee, D.B. Loeb, F.A. Mapa, E. McClelland, N.C. Meyer, G.A. Mintier, N. Moeller, T. Moore, E. Morikang, C.E. Prass, L. Quintana, S.M. Starnes, R.C. Schatzman, K.J. Brunke, D.T. Drayna, N.J. Risch, B.R. Bacon, R.K. Wolff, "A novel MHC class-I-like gene is mutated in patients with hereditary hemochromatosis," Nature Genetics, 13:399-408, 1996. (Cited more than 236 times since publication) Comments by Roger K. Wolff, vice president of genetics, Progenitor Inc., Menlo Park, Calif.
The conventional method of identifying a mutant gene's locale is by analyzing linkage, the relationship between genes on the same chromosome that causes ...