Genetics

CLEVER METHOD: Roger K. Wolff of Progenitor Inc. led a research team that used linkage disequilibrium mapping to locate the gene for hereditary hemochromatosis. J.N. Feder, A. Gnirke, W. Thomas, Z. Tsuchihashi, D.A. Ruddy, A. Basava, F. Dormishian, R. Domingo, M.C. Ellis, A. Fullan, L.M. Hinton, N.L. Jones, B.E. Kimmel, G.S. Kronmal, P. Lauer, V.K. Lee, D.B. Loeb, F.A. Mapa, E. McClelland, N.C. Meyer, G.A. Mintier, N. Moeller, T. Moore, E. Morikang, C.E. Prass, L. Quintana, S.M. Starnes, R.C.

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CLEVER METHOD: Roger K. Wolff of Progenitor Inc. led a research team that used linkage disequilibrium mapping to locate the gene for hereditary hemochromatosis.

J.N. Feder, A. Gnirke, W. Thomas, Z. Tsuchihashi, D.A. Ruddy, A. Basava, F. Dormishian, R. Domingo, M.C. Ellis, A. Fullan, L.M. Hinton, N.L. Jones, B.E. Kimmel, G.S. Kronmal, P. Lauer, V.K. Lee, D.B. Loeb, F.A. Mapa, E. McClelland, N.C. Meyer, G.A. Mintier, N. Moeller, T. Moore, E. Morikang, C.E. Prass, L. Quintana, S.M. Starnes, R.C. Schatzman, K.J. Brunke, D.T. Drayna, N.J. Risch, B.R. Bacon, R.K. Wolff, "A novel MHC class-I-like gene is mutated in patients with hereditary hemochromatosis," Nature Genetics, 13:399-408, 1996. (Cited more than 236 times since publication)

Comments by Roger K. Wolff, vice president of genetics, Progenitor Inc., Menlo Park, Calif.

The conventional method of identifying a mutant gene's locale is by analyzing linkage, the relationship between genes on the same chromosome that causes ...

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