Group Identifies Antiapoptosis Mechanism

For this article, Jennifer Fisher Wilson interviewed Albert Baldwin Jr., professor of biology and associate director of the Lineberger Comprehensive Cancer Center, University of North Carolina. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more than the average paper of the same type and age. C.Y. Wang, M.W. Mayo, R.G. Korneluk, D.V. Goeddel, A.S. Baldwin, "NF-kB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation," Science, 281:1680-3, Sept. 11, 1998. (Cited in more than 184 papers since publication) Cells are constantly challenged with stimuli that could lead to cell death. And yet most survive. The question of how some cells escape programmed death, or apoptosis, has long baffled scientists. Recently, though, a surge of research focusing on the nuclear factor kappa B (NF-kB) has begun to elucidate at least one mechanism for protection against cell ...