For this article, Steve Bunk interviewed Jörn E. Schmitz, instructor in medicine, and Keith A. Reimann, associate professor of medicine, both of Beth Israel Deaconess Medical Center, Harvard University Medical School. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.


J.E. Schmitz, M.J. Kuroda, S. Santra, V.G. Sasseville, M.A. Simon, M.A. Lifton, P. Racz, K. Tenner-Racz, M. Dalesandro, B.J. Scallon, J. Ghrayeb, M.A. Forman, D.C. Montefiori, E.P. Rieber, N.L. Letvin, K.A. Reimann, "Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes," Science, 283:857-60, Feb. 5, 1999. (Cited in more than 130 papers since publication)

One of many difficulties facing those who would develop a successful HIV-1 vaccine is trying to understand which components of the immune response are most capable of controlling the...

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