Hooked on a Hunt

Arguably the biggest fishing expedition in the history of cell biology is drawing to a close. What have we caught?

By Andrea Gawrylewski

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1 The receptor showed a remarkable homology to the seven-transmembrane receptor rhodopsin, involved in nighttime light perception, and the only receptor known at the time to act through a G protein. The new beta 2AR genomic sequence suggested that a new family of receptors might exist, and they all might share a common structure.

Though it was early in his career, Civelli, then at the Vollum Institute at the Oregon Health & Science University, gambled that he could use the sequence of the beta 2AR gene as a screen for similar receptor genes. In the same year that the Duke group published, Civelli recloned beta 2AR and used it as a probe to screen a rat genomic library. At the time,...

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