M.J. Birnbaum, Identification of a novel gene encoding an insulin-responsive glucose transporter protein, Cell, 57:305-15, 21 April 1989.
Morris J. Birnbaum (Harvard Medical School, Boston): Almost 10 years prior to the publication of this paper, other researchers formulated a model to explain the rapid and reversible insulin-stimulated increase in glucose uptake in responsive target tissues: the hormone effects the redistribution of hexose transporter proteins from a latent intracellular compartment to the plasma membrane (S.W. Cushman and L.J. Wardzala, J. Biol. Chem., 255:4758-62, 1980; and K. Suzuki and T. Kono, Proceedings of the National Academy of Sciences, USA, 77:2542-5, 1980). Since that time, there has been a striking lack of correlation between estimates of transporter translocation and measurements of increased transport. One possible explanation for this discrepancy was the existence of another glucose transporter expressed in insulin-responsive tissues and not recognized by the then-available antibody probes.
This paper, as well as ...
