Hot Papers

The articles listed below, all less than two years old, have received a substantially greater number of citations than others of the same type and vintage, according to data from the Science Citation Index of the Institute for Scientific Information, Philadelphia. Why have these research reports become such standouts? A comment following each reference, supplied to The Scientist by one of the authors, attempts to provide an answer. K.V. Visvanathan, S. Goodbourn, "Double-stranded RNA activates

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The articles listed below, all less than two years old, have received a substantially greater number of citations than others of the same type and vintage, according to data from the Science Citation Index of the Institute for Scientific Information, Philadelphia. Why have these research reports become such standouts? A comment following each reference, supplied to The Scientist by one of the authors, attempts to provide an answer.
K.V. Visvanathan, S. Goodbourn, "Double-stranded RNA activates binding of NFkB to an inducible element in the human á-interferon promoter," The EMBO Journal, 8, 1129-38, April 1989.

Kanna V. Visvanathan (Imperial Cancer Research Fund Laboratories, London, England): "Our work showed that induction of alpha-interferon expression by double-stranded RNA involved the induction of a sequence-specific DNA binding activity. This activity was identified as NF-kB (nuclear factor kB), dubbed thus on account of its binding to the k immunoglobulin enhancer and apparent B cell-specific expression. ...

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