As an advocate for the needs of researchers working at the forefronts of genomic research, Integrated DNA Technologies (IDT) releases its latest CRISPR enzyme Alt-R® Cas12a (Cpf1) Ultra. Cas12a Ultra is a powerful addition to IDT’s Alt-R CRISPR enzyme arsenal – its vastly improved performance makes it easier to achieve precision genome editing at new sites across genomes.
Publication of the Cas12a system in 2015 generated considerable interest among researchers seeking new enzymes for genome editing experiments, particularly due to its unique PAM site (“TTTV”) that greatly expanded the number of potential editing sites in the genome beyond that of Cas9 (“NGG”). IDT developed a novel mutant of the Acidaminococcus sp. BV3L6 Cas12a (Cpf1), called Cas12a Ultra. The new mutant enzyme has enhanced editing activity, reaching or exceeding the performance of Cas9. The new Cas12a Ultra also retains activity across a wider temperature range than the wild type enzyme, making ...
