Edited by Neeraja Sankaran
K.L. Rock, C. Gramm, L. Rothstein, K. Clark, R. Stein, L. Dick, D. Hwang, A.L. Goldberg, "Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules," Cell, 78:761-71, 1994. (Cited in nearly 70 publications through November 1995) Comments by Kenneth Rock, Dana-Farber Cancer Institute, Boston
This paper discusses the biochemistry of the cellular processes that allow the immune system to recognize various peptides-pieces of protein-present on the surfaces of different cells.
ON THE SURFACE: Dana-Farber Cancer Institute's Kenneth Rock and his colleagues determined how MHC-associated peptides are generated.
One of the main interests of the authors of this paper was to determine how these peptides are generated. "Our hypothesis was that the proteasome-a large, multi-subunit protein complex with protein-degrading activity-is somehow involved in breaking down foreign proteins into pieces which are then transported to ...
