H. Yssel, R.D.W. Malefyt,M-G. Roncarolo, J.S. Abrams, R. Lahesmaa, H. Spits, J.E. de Vries, "IL-10 is produced by subsets of human CD4+ T-cell clones and peripheral blood T cells," Journal of Immunology, 149:2378-84, 1992. Jan E. de Vries (DNAX Research Institute, Palo Alto, Calif.): "This paper characterizes the production of the cytokine interleukin-10 (IL-10) by human T lymphocytes and T-cell clones.
"Following antigenic stimulation, T lymphocytes are able to produce cytokines. Cytokines are pleiotropic `hormones' of the immune system that regulate proliferation, differentiation, and function of T lymphocytes, B lymphocytes, natural killer (NK) cells, and monocytes/macrophages. In both mice and humans, CD4+ T lymphocytes can be divided into subsets based on the production of different cytokines, whose production patterns correlate with T-cell functions.
"While studying cytokine production in humans, we observed that IL-10 was produced by several different subsets of T cells in addition to the CD4+ clones belonging to ...
