These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool
N. Sato et al., "Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor,"
Sato and colleagues argue that inhibition of glycogen synthase kinase-3 (GSK3), resulting in activation of the Wnt-signaling pathway, is sufficient to maintain self-renewal of murine and human embryonic stem cells. These observations will no doubt stimulate intense interest.
S.S. Diebold et al., "Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA,"
These are the first studies (see also F. Heil et al., Science, 303:1526–9, March 5, 2004) to show that single-stranded RNA is the physiological ligand of toll-like receptors 7 and 8 (TLR7 and TLR8). To function as a TLR ...
