Interpreting the Signaling of Notch

For this article, Eugene Russo interviewed Mark E. Fortini, an assistant professor of genetics at the University of Pennsylvania, Iva Greenwald, a Howard Hughes Medical Institute investigator and professor of biochemistry at the Columbia University College of Physicians and Surgeons, Raphael Kopan, an associate professor of molecular biology and pharmacology at Washington University in St. Louis, and Michael Wolfe, an associate professor of neurology at Harvard Medical School. Data from the Web

Written byEugene Russo
| 6 min read

Register for free to listen to this article
Listen with Speechify
0:00
6:00
Share

For this article, Eugene Russo interviewed Mark E. Fortini, an assistant professor of genetics at the University of Pennsylvania, Iva Greenwald, a Howard Hughes Medical Institute investigator and professor of biochemistry at the Columbia University College of Physicians and Surgeons, Raphael Kopan, an associate professor of molecular biology and pharmacology at Washington University in St. Louis, and Michael Wolfe, an associate professor of neurology at Harvard Medical School. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to100 times more often than the average paper of the same type and age. B. De Strooper, W. Annaert, P. Cupers, P. Saftig, K. Craessaerts, J.S. Mumm, EH Schroeter, V. Schrijvers, M.S. Wolfe, W.J. Ray, A. Goate, R. Kopan, "A presenilin-1-dependent g-secretase-like protease mediates release of Notch intracellular domain," Nature, 398:518-22, April 8, 1999. (Cited in 172 papers) G. Struhl, I. Greenwald, "Presenilin is required for activity ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

Published In

Share
July Digest 2025
July 2025, Issue 1

What Causes an Earworm?

Memory-enhancing neural networks may also drive involuntary musical loops in the brain.

View this Issue
Explore synthetic DNA’s many applications in cancer research

Weaving the Fabric of Cancer Research with Synthetic DNA

Twist Bio 
Illustrated plasmids in bright fluorescent colors

Enhancing Elution of Plasmid DNA

cytiva logo
An illustration of green lentiviral particles.

Maximizing Lentivirus Recovery

cytiva logo
Explore new strategies for improving plasmid DNA manufacturing workflows.

Overcoming Obstacles in Plasmid DNA Manufacturing

cytiva logo

Products

sartorius-logo

Introducing the iQue 5 HTS Platform: Empowering Scientists  with Unbeatable Speed and Flexibility for High Throughput Screening by Cytometry

parse_logo

Vanderbilt Selects Parse Biosciences GigaLab to Generate Atlas of Early Neutralizing Antibodies to Measles, Mumps, and Rubella

shiftbioscience

Shift Bioscience proposes improved ranking system for virtual cell models to accelerate gene target discovery

brandtechscientific-logo

BRANDTECH Scientific Launches New Website for VACUU·LAN® Lab Vacuum Systems