For this article, Eugene Russo interviewed Mark E. Fortini, an assistant professor of genetics at the University of Pennsylvania, Iva Greenwald, a Howard Hughes Medical Institute investigator and professor of biochemistry at the Columbia University College of Physicians and Surgeons, Raphael Kopan, an associate professor of molecular biology and pharmacology at Washington University in St. Louis, and Michael Wolfe, an associate professor of neurology at Harvard Medical School. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to100 times more often than the average paper of the same type and age.

B. De Strooper, W. Annaert, P. Cupers, P. Saftig, K. Craessaerts, J.S. Mumm, EH Schroeter, V. Schrijvers, M.S. Wolfe, W.J. Ray, A. Goate, R. Kopan, "A presenilin-1-dependent g-secretase-like protease mediates release of Notch intracellular domain," Nature, 398:518-22, April 8, 1999. (Cited in 172 papers)

G. Struhl, I....

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