Keeping Cancer in Check: Innate Immunity and Checkpoint Inhibitors

Keeping Cancer in Check: Innate Immunity and Checkpoint Inhibitors from thescientistllc on Vimeo.

Immune responses are controlled by an exquisite system of stimulatory and inhibitory checkpoints. Cancer cells often find a way to co-opt these checkpoints to avoid being attacked by the immune system. There is growing interest in blocking inhibitory innate immune checkpoints such as the “don’t eat me” signal, CD47, which is commonly overexpressed on cancer cells, and the TAM receptor family of tyrosine kinases. Also, small molecule agonists against STING—a protein that ramps up production of interferons and cytokines—are major targets on the radar for therapeutic development, as well as molecules that target Toll-like Receptors (TLRs) and RIG-I-like Receptors (RLRs). Join us for a discussion about first-in-class STING agonists and innate immune checkpoints in cancer.

Topics to be covered:

• Immune Oncology beyond PD1: preclinical and first clinical data using ADU-S100, a first-in-class STING agonist
• Mechanism of...