In just over a decade, genetically engineered mice have brought dramatic changes to the biomedical sciences, offering basic researchers ways to detect the influences of single genes and more clinically oriented investigators compellingly close models of human disease.

The following suppliers are among those providing transgenic and knockout mice to researchers.

Charles River Laboratories
251 Ballardvale St.
Wilmington, Mass. 01887
(508) 658-6000

Products: OncoMice (five strains, transgenes are various oncogenes); apo-A-1 (transgene is human apolipoprotein A-1); ImmortoMouse (transgene is an SV40 gene allowing immortality of cells in culture). Call for details and prices.

DNX 303B College Rd. East
Princeton Forrestal Ctr.
Princeton, N.J. 08540
(609) 520-0300
Fax: (609) 520-9864

Products: Premium mouse service (microinjection) with PCR $7,250; with slot blot analysis $7,500; with southern blot analysis $8,000. Shipping and handling $100. Basic mouse service $4,000 (researcher identifies transgenics).

Exemplar Corp.
1 Innovation Dr.
Worcester, Mass....

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