Insomnia, late-night habits, and irregular sleep schedules may be linked to the onset of Alzheimer's disease, says a new linkurl:study; published online today in ScienceExpress.
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"Our results are preliminary evidence that sleep abnormalities midlife could put people at risk of Alzheimer's disease later," said linkurl:David Holtzman,;, a coauthor of the study and a neurologist at the Washington University School of Medicine. The group found that the concentration of amyloid-beta, a peptide whose build-up is linked to the onset of the disease, significantly increases during periods of sleep deprivation. Alzheimer's disease is triggered as amyloid-beta transforms from a soluble, monomeric form into oligomers, protofibrils, and fibrils that build up as plaque in the brain's interstitial fluid, damaging neurons. linkurl:Jae-Eun Kang; at Washington University in St. Louis and her colleagues were studying the physiological factors regulating this process when they stumbled upon the connection between sleep and Alzheimer's...

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