M.W. Schwartz, D.G. Baskin, T.R. Bukowski, J.L. Kuijper, D. Foster, G. Lasser, D.E. Prunkard, D. Porte Jr., S.C. Woods, R.J. Seeley, D.S. Weigle, "Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in ob/ob Mice," Diabetes, 45: 531-5, 1996. (Cited more than 150 times since publication)

Comments by Michael W. Schwartz, professor of medicine, University of Washington and Puget Sound Health Care System.

Few discoveries like that of the obese ( ob ) gene in 1994 have had such a sweeping effect on science. Traditionally regarded as an affliction due to the weak will of its sufferers, obesity is now considered a disease much like diabetes by many researchers and physicians. By 1995, scientists were discovering the enormous therapeutic potential of leptin, a protein encoded by the ob gene. Five research teams independently reported that doses of the protein normalized food intake,...

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