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Proteomic Mass Spectrometry Equipment

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Courtesy of Ciphergen

Ciphergen's SELDI process, a MALDI variant that includes a surface-based enrichment step

Early in the twentieth century, scientists puzzled over the observation that certain elements that were otherwise physically indistinguishable from each other nevertheless exhibited different radioactive decay characteristics. These elements would ultimately come to be known as isotopes, but at the time this concept was a mystery. Then, in 1912 J. J. Thomson designed a device in which positive rays generated by the ionization of a gas in a discharge tube were subjected to both magnetic and electric fields, and separated the two isotopes of neon, with masses of 20 and 22. Thus was born the first mass spectrometer, a device that, in conjunction with microarray analysis and two-dimensional gel electrophoresis (2DE), is now driving the proteomics revolution forward. Today, researchers use mass spectrometers to identify...

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