In the medical research arena, the M.D.'s have generally stuck with their stethoscopes, leaving the work of discovering to the Ph.D.'s. But at the Mayo Clinic in Rochester, Minn., a research group led by cardiologist John C. Burnett, Jr., and composed entirely of medical doctors is charging ahead to decipher the physiologic role of endothelin, a peptide that causes narrowing of the blood vessels.

For the most part, endothelin has been the focus of investigations by molecular biologists and biochemists--not clinicians. During the past year, however, Burnett and his team have added a new dimension to endothelin research; a dimension that has received considerable attention from the rest of the research community.

John Burnett's team has been on a winning streak in the past few months as the Mayo group of clinicians had two more endothelin studies accepted for publication: one appeared in the August issue of the American Journal...

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