The need for a journal that emphasized the causative mechanisms of cancer at the molecular level became apparent in 1987, when the burgeoning field of molecular biology made it possible to examine carcinogenesis at a more intimate level. In conjunction with the University of Texas M.D. Anderson Cancer Center and Wiley-Liss Inc. of New York, we started Molecular Carcinogenesis as a peer-reviewed forum for work on the molecular mechanisms of carcinogenesis.
Advances in molecular biology have enabled us to move from what University of Maryland pathology professor Ellen Silbergeld referred to in the article as "hitting an animal over the head and seeing which organ falls out first" to determining the precise physical interactions between carcinogens and the DNA and proteins of target cells.
For example, in a recent issue of Molecular Carcinogenesis (4:176-9, 1991), C. Anita H. Bigger of the National Cancer Institute and associates reported that the anti ...
