In 1988, The Scientist featured the most highly cited papersin the life sciences. All were method papers, with the venerable Lowry protein measurement technique nominated as the King of Citations.1

Looking at papers published in the past 10 years using ISI Essential Science Indicators, we found that method papers still rule, though the focus has changed from measuring cell constituents to conducting computer analysis of nucleic acid and protein sequences.

- Alexander Grimwade

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