Mitochondria as a Control in Apoptosis

For this article, Jennifer Fisher Wilson interviewed Guido Kroemer, Research Director, Centre National de la Recherche Scientifique, Institut Gustave Roussy in Villejuif, France. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. S.A. Susin, H.K. Lorenzo, N. Zamzami, I. Marzo, B.E. Snow, G.M. Brothers, J. Mangion, E. Jacotot, P. Costantini, M. Loeffler, N. Larochette, D.R. Goodlett, R. Aebersold, D.P. Siderovski, J.M. Penninger, G. Kroemer, "Molecular characterization of mitochondrial apoptosis-inducing factor," Nature, 397:441-6, Feb. 4, 1999. (Cited 263 times) Less than a decade ago, scientists at Centre National de la Recherche Scientifique in Villejuif, France, noticed a connection between decreased mitochondrial transmembrane potential and cell death. Thinking that this might indicate that mitochondria play a larger role in apoptosis than previously thought, they pursued the connection and soon established that ...