Molecular Biology

S. Akira, T. Hirano, T. Taga, T. Kishimoto, "Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)," FASEB Journal, 4:2860-67, 1990. Shizuo Akira (Institute for Molecular and Cellular Biology, Osaka University, Japan): "Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a central role in defense mechanisms, including the immune response, acute phase reaction, and hematopoiesis. Since our success in the cloning of the IL-6 cDNA in 1985, our group has been study


Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

S. Akira, T. Hirano, T. Taga, T. Kishimoto, "Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)," FASEB Journal, 4:2860-67, 1990.

Shizuo Akira (Institute for Molecular and Cellular Biology, Osaka University, Japan): "Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a central role in defense mechanisms, including the immune response, acute phase reaction, and hematopoiesis. Since our success in the cloning of the IL-6 cDNA in 1985, our group has been studying IL-6 action from various aspects, using molecular and cellular biological techniques. We have clarified biological function, pathological involvement of IL-6, the IL-6 receptor system, and IL-6 gene regulation. As a result, the cloning of the IL-6 receptor complexes has disclosed the existence of a novel cytokine superfamily and a two-chain- signal transduction system, which has now been identified in other cytokine receptor systems. Studies on IL-6 gene regulation have led to the cloning of ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here
3D illustration of a gold lipid nanoparticle with pink nucleic acid inside of it. Purple and teal spikes stick out from the lipid bilayer representing polyethylene glycol.
February 2025, Issue 1

A Nanoparticle Delivery System for Gene Therapy

A reimagined lipid vehicle for nucleic acids could overcome the limitations of current vectors.

View this Issue
Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

sartorius logo
Considerations for Cell-Based Assays in Immuno-Oncology Research

Considerations for Cell-Based Assays in Immuno-Oncology Research

Lonza
An illustration of animal and tree silhouettes.

From Water Bears to Grizzly Bears: Unusual Animal Models

Taconic Biosciences
Sex Differences in Neurological Research

Sex Differences in Neurological Research

bit.bio logo

Products

Tecan Logo

Tecan introduces Veya: bringing digital, scalable automation to labs worldwide

Explore a Concise Guide to Optimizing Viral Transduction

A Visual Guide to Lentiviral Gene Delivery

Takara Bio
Inventia Life Science

Inventia Life Science Launches RASTRUM™ Allegro to Revolutionize High-Throughput 3D Cell Culture for Drug Discovery and Disease Research

An illustration of differently shaped viruses.

Detecting Novel Viruses Using a Comprehensive Enrichment Panel

Twist Bio