Molecular Biology

C. Ellis, M. Moran, F. McCormick, T. Pawson, "Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases," Nature, 343, 377-81, 25 January 1990. D.R. Kaplan, D.K. Morrison, G. Wong, F. McCormick, L.T. Williams, "PDGF b-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex," Cell, 61, 125-33, 6 April 1990. Frank McCormick (Cetus Corp., Emeryville, Calif.): "GTPase-activating protein (GAP) is a protein that bin


Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

C. Ellis, M. Moran, F. McCormick, T. Pawson, "Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases," Nature, 343, 377-81, 25 January 1990.

D.R. Kaplan, D.K. Morrison, G. Wong, F. McCormick, L.T. Williams, "PDGF b-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex," Cell, 61, 125-33, 6 April 1990.

Frank McCormick (Cetus Corp., Emeryville, Calif.): "GTPase-activating protein (GAP) is a protein that binds to p21ras and converts it from the active form (GTP-bound) to the inactive form (GDP-bound). These papers show that GAP also binds to activated platelet-derived growth factor (PDGF)-receptor and to two phosphotyrosine-containing proteins designated p190 and p62. These observations raise the strong possibility that GAP is part of an illusive link between tyrosine kinase signaling pathways to those involving p21ras. Association of GAP with activated PDGF-receptor could have various intriguing consequences: GAP's ability to down-regulate p21ras could be compromised, ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here
3D illustration of a gold lipid nanoparticle with pink nucleic acid inside of it. Purple and teal spikes stick out from the lipid bilayer representing polyethylene glycol.
February 2025, Issue 1

A Nanoparticle Delivery System for Gene Therapy

A reimagined lipid vehicle for nucleic acids could overcome the limitations of current vectors.

View this Issue
Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

sartorius logo
Considerations for Cell-Based Assays in Immuno-Oncology Research

Considerations for Cell-Based Assays in Immuno-Oncology Research

Lonza
An illustration of animal and tree silhouettes.

From Water Bears to Grizzly Bears: Unusual Animal Models

Taconic Biosciences
Sex Differences in Neurological Research

Sex Differences in Neurological Research

bit.bio logo

Products

Photo of a researcher overseeing large scale production processes in a laboratory.

Scaling Lentiviral Vector Manufacturing for Optimal Productivity

Thermo Fisher Logo
Collage-style urban graphic of wastewater surveillance and treatment

Putting Pathogens to the Test with Wastewater Surveillance

An illustration of an mRNA molecule in front of a multicolored background.

Generating High-Quality mRNA for In Vivo Delivery with lipid nanoparticles

Thermo Fisher Logo
Tecan Logo

Tecan introduces Veya: bringing digital, scalable automation to labs worldwide