B. Mosley, M.P. Beckmann, C.J. March, R.L. Idzerda, S.D. Gimpel, T. VandenBos, D. Friend, A. Alpert, D. Anderson, J. Jackson, J.M. Wignall, C. Smith, B. Gallis, J.E. Sims, D. Urdal, M.B. Widmer, D. Cosman, L.S. Park, "The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms," Cell, 59, 335-48, 20 October 1989.
David Cosman (Immunex Corp., Seattle): "I can think of several reasons why our paper has been cited. There is substantial interest in the pleiotropic biological activities of interleukin 4 (IL-4), and the molecular cloning of the IL-4 receptor provides a necessary first step toward understanding how IL-4 transduces so many different signals in different cell types. The structure of the extracellular, ligand-binding domain of the receptor showed significant homology with other cytokine receptors (IL-2Rb, erythropoietin, IL-6), and we and others have since extended this observation to define an extensive new family of cytokine receptors. ...
