Molecular Genetics

X.D. Wang, R. Sato, M.S. Brown, X.X. Hua, J.L. Goldstein, "Srebp-1, a membrane-bound transcription factor released by sterol-regulated proteolysis," Cell, 77:53-62, 1994. (Cited in more than 65 publications as of February 1996) Comments by Joseph L. Goldstein, University of Texas Southwestern Medical Center SURPRISED: Joseph Goldstein investigates cholesterol control. The work reported in this paper reveals the mechanism for transcriptional control of the genes that regulate cholesterol in

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X.D. Wang, R. Sato, M.S. Brown, X.X. Hua, J.L. Goldstein, "Srebp-1, a membrane-bound transcription factor released by sterol-regulated proteolysis," Cell, 77:53-62, 1994. (Cited in more than 65 publications as of February 1996)

SURPRISED: Joseph Goldstein investigates cholesterol control.

The work reported in this paper reveals the mechanism for transcriptional control of the genes that regulate cholesterol in cells and in the bloodstream. For years, Joseph L. Goldstein, chairman and professor of molecular genetics at the University of Texas Southwestern Medical Center in Dallas, and his University of Texas medical center colleague Michael Brown, the Paul J. Thomas Professor of Genetics and director of the Jonsson Center for Molecular Genetics, have studied certain cholesterol-regulating proteins, including the low-density lipid (LDL) protein receptor. LDL is the major molecule that controls blood cholesterol. Its receptor is encoded by one of the genes regulated by the transcription factor, Srebp-1.

"The paper describes a proteolytic ...

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