Skip to main content

Molecular Genetics

X.D. Wang, R. Sato, M.S. Brown, X.X. Hua, J.L. Goldstein, "Srebp-1, a membrane-bound transcription factor released by sterol-regulated proteolysis," Cell, 77:53-62, 1994. (Cited in more than 65 publications as of February 1996) Comments by Joseph L. Goldstein, University of Texas Southwestern Medical Center SURPRISED: Joseph Goldstein investigates cholesterol control. The work reported in this paper reveals the mechanism for transcriptional control of the genes that regulate cholesterol in

Written bySteven Benowitz
| 3 min read

Register for free to listen to this article
Listen with Speechify
0:00
3:00

X.D. Wang, R. Sato, M.S. Brown, X.X. Hua, J.L. Goldstein, "Srebp-1, a membrane-bound transcription factor released by sterol-regulated proteolysis," Cell, 77:53-62, 1994. (Cited in more than 65 publications as of February 1996)

Joseph Goldstein
SURPRISED: Joseph Goldstein investigates cholesterol control.
The work reported in this paper reveals the mechanism for transcriptional control of the genes that regulate cholesterol in cells and in the bloodstream. For years, Joseph L. Goldstein, chairman and professor of molecular genetics at the University of Texas Southwestern Medical Center in Dallas, and his University of Texas medical center colleague Michael Brown, the Paul J. Thomas Professor of Genetics and director of the Jonsson Center for Molecular Genetics, have studied certain cholesterol-regulating proteins, including the low-density lipid (LDL) protein receptor. LDL is the major molecule that controls blood cholesterol. Its receptor is encoded by one of the genes regulated by the transcription factor, Srebp-1.

"The paper describes a proteolytic ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?
Add The Scientist as a preferred source on Google

Add The Scientist as a preferred Google source to see more of our trusted coverage.

Meet the Author

Published In

Related articles background image
The Scientist Digest cover September 2026
September 2026

Multiplex Microscopy Becomes Easier with Encoded Antibodies

A new system that enables researchers to uniquely tag monoclonal antibodies for use in microscopy could help simplify complex imaging studies.

View this Issue
Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Alamar Biosciences logo
Best Practices for qPCR Assay Design and Optimization

Best Practices for qPCR Assay Design and Optimization

Bio-Rad
Beyond the Basics: Strategies for Single-Cell and Spatial Transcriptomics Analysis

Beyond the Basics: Strategies for Single-Cell and Spatial Transcriptomics Analysis

bioxcell
Scientist reviewing cellular and molecular data on a computer in a laboratory.

Building Translation-Ready Biomarkers with Connected Workflows

Danaher Logo

Products

Closeup image of a multi channel pipette dispensing pink liquid into a 96-well plate.

The ASSIST PLUS pipetting robot for affordable workflow automation

Integra Logo
Single cells in suspension

Rapidly isolate primary cells and make uniform single-cell suspensions with Corning® Cell Strainers

Corning logo
Abstract image representing cell membranes linked together.

CellBrite® Steady Membrane Stain: Cell surface staining built for real-time imaging

Biotium
sino biological logo

Monod Bio Licenses AI-designed Protein Technologies to SignalChem Biotech for Custom Discovery Assays