Edited by: Steve Bunk

WEIGHT CONTROL: Leptin might regulate body weight by signaling the size of the fatty tissue mass, research led by Jeffrey Friedman shows.
M. Maffei, J. Haalas, E. Ravussin, R.E. Pratley, G.H. Lee, Y. Zhang, H. Fei, S. Kim, R. Lallone, S. Ranganathan, P.A. Kern, J.M. Friedman, "Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects," Nature Medicine, 1:1155-61, 1995. (Cited in 196 papers through August 1997)

Comments by Jeffrey M. Friedman, Howard Hughes Medical Institute, Rockefeller University.

"Leptin is assuming an increasingly prominent role in our understanding of how weight is regulated," says Jeffrey M. Friedman, a professor of molecular genetics in the Howard Hughes Medical Institute at Rockefeller University. "A lot of useful information can be gleaned quickly by measuring leptin levels."

He should know, having led the research team that first cloned the...

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