With Lasergene 16, DNASTAR has introduced an all-new protein design tool that enables researchers to identify residues that influence protein fold stability, by introducing specific variants to the wild-type structure or by scanning for hot-spot residues. Protein design simulations take seconds to complete – allowing researchers to perform high-throughput scanning of protein variations to support their downstream analysis and experimentation. Findings from the protein design workflow can also be used to guide PCR based site-directed mutagenesis using the Lasergene Molecular Biology software. By integrating structure and sequence-based analysis, Lasergene users can expect to save days of time on mutagenesis experiments.
NovaFold, part of Lasergene Protein and powered by the award-winning I-TASSER algorithm for protein structure prediction, now further enhances the quality of its world-leading structure predictions. A new structure-refinement protocol improves bond geometries, removes atomic clashes, and creates energetically minimized structure models. These improvements amount to more accurate structure models ...
