Neurochemistry

Edited by: Steve Bunk THERE THEY ARE: Harvard's Wilma Wasco and colleagues found the subcellular locales of the presenilins, in the endoplasmic reticulum and the Golgi complex. D.M. Kovacs, H.J. Fausett, K.J. Page, T.W. Kim, R.D. Moir, D.E. Merriam, R.D. Hollister, O.G. Hallmark, R. Mancini, K.M. Fstein, B.T. Hyman, R.E. Tanzi, W. Wasco, "Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells," Nature Medicine, 2:2

| 3 min read

Register for free to listen to this article
Listen with Speechify
0:00
3:00
Share

Edited by: Steve Bunk


THERE THEY ARE: Harvard's Wilma Wasco and colleagues found the subcellular locales of the presenilins, in the endoplasmic reticulum and the Golgi complex.
D.M. Kovacs, H.J. Fausett, K.J. Page, T.W. Kim, R.D. Moir, D.E. Merriam, R.D. Hollister, O.G. Hallmark, R. Mancini, K.M. Fstein, B.T. Hyman, R.E. Tanzi, W. Wasco, "Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells," Nature Medicine, 2:224-9, 1996. (Cited in more than 115 publications as of January 1998) Comments by Wilma Wasco, Genetics and Aging Unit and Department of Neurology, Massachusetts General Hospital-East, Harvard Medical School

At times, neurochemical research resembles a particularly frustrating detective story, in which each clue creates yet more mystery. Such is the case concerning the principal subject of research in this paper, two novel human genes called the presenilins (PS1 and PS2). Both the normal biological role of the ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

  • Steve Bunk

    This person does not yet have a bio.

Published In

Share
A greyscale image of cells dividing.
March 2025, Issue 1

How Do Embryos Know How Fast to Develop

In mammals, intracellular clocks begin to tick within days of fertilization.

View this Issue
iStock: Ifongdesign

The Advent of Automated and AI-Driven Benchwork

sampled
Discover the history, mechanics, and potential of PCR.

Become a PCR Pro

Integra Logo
3D rendered cross section of influenza viruses, showing surface proteins on the outside and single stranded RNA inside the virus

Genetic Insights Break Infectious Pathogen Barriers

Thermo Fisher Logo
A photo of sample storage boxes in an ultra-low temperature freezer.

Navigating Cold Storage Solutions

PHCbi logo 

Products

Sapio Sciences

Sapio Sciences Makes AI-Native Drug Discovery Seamless with NVIDIA BioNeMo

DeNovix Logo

New DeNovix Helium Nano Volume Spectrophotometer

Olink Logo

Olink® Reveal: Accessible NGS-based proteomics for every lab

Olink logo
Zymo Logo

Zymo Research Launches the Quick-16S™ Full-Length Library Prep Kit