Edited by: Stephen P. Hoffert
R.G. Will, J.W. Ironside, M. Zeidler, S.N. Cousens, K. Estibeiro, A. Alperovitch, S. Poser, M. Pocchiari, A. Hofman, P.G. Smith, "A new variant of Creutzfeldt-Jakob disease in the U.K.," Lancet, 347:921-5, 1996. (Cited in more than 230 publications to date)

Comments by R.G. Will, National Creutzfeldt-Jakob Disease Surveillance Unit, Edinburgh, Scotland

On Aug. 1, 1996, an international research team sent scientific, economic, and political shock waves throughout the world when they announced the discovery of a variant of Creutzfeldt-Jakob disease (CJD), the human strain of transmissible spongiform encephalopathy (TSE). With evidence possibly linking the emergence of a new variant of CJD (vCJD) with an epidemic of bovine spongiform encephalopathy (BSE) in the United Kingdom, health officials around the world intensified efforts to cull afflicted cattle from herds and prevent infected meat from entering the food chain.

CEREBRAL PERFORATIONS: Characteristic vacuoles, or small holes,...

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