S.Q. Jing, D.Z. Wen, Y.B. Yu, P.L. Hoist, Y. Luo, M. Fang, R. Tamir, L. Antonio, Z. Hu, R. Cupples, J. Louis, S. Hu, B.W. Altrock, G.M. Fox, "GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF," Cell, 85:1113-24, 1996. (Cited more than 170 times since publication)

Comments made by Gary M. Fox, Department of Molecular Genomics, Amgen Inc., Thousand Oaks, Calif.

Gary M. Fox, left, and Shuqian Jing

Below the spatula and to the left is the substantia nigra, the area that degenerates in Parkinson's disease and the target sight for GDNF.
Neurotrophic factors, human proteins that protect and promote the growth of certain nerve cells, have garnered much attention from researchers recently. And for good reason: They're believed to have the potential to halt--or, in some cases, even reverse--the nerve damage that can result from neurodegenerative diseases. One...

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