New NIH Procedures To Shield Clinicians From Grants Bias

As Mark Twain may--or, according to some sources, may not--have said about the weather, everybody has grumbled for years that National Institutes of Health peer-review study sections are stacked against clinical research, but nobody ever does anything about it. Now, that's changing, along with a lot of other standard operating procedures in NIH's peer-review system. NIH's Center for Scientific Review (CSR), which runs the panels that review about 70 percent of NIH grant applications, is about

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NIH's Center for Scientific Review (CSR), which runs the panels that review about 70 percent of NIH grant applications, is about to try several new devices to shield clinical-research proposals from unfair competition with laboratory experiments in peer-review panels dominated by basic scientists.

By the end of this year, CSR Director Ellie Ehrenfeld plans to create two new "special emphasis panels" for proposed patient-oriented experiments in oncology and cardiology, and to test a variety of approaches for clinical proposals that still don't seem to fit anywhere.

NEW DIRECTION: Under Director Ellie Ehrenfeld, NIH's Center for Scientific Review is trying to change the method and speed of grant approvals. Study-section bias has been a long-standing complaint of clinical researchers seeking NIH grants. Evaluating clinical-research proposals "does take special expertise," says Timothy Ley of Washington University in St. Louis, president of the American Society for Clinical Investigation (ASCI), and many CSR study ...

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