Scientists have devised a new way to make sugar-linked proteins, an important step towards understanding a key type of protein modification and refining drug therapies that utilize the so-called glycoproteins -- as well as the subject of two high-profile papers that were recently retracted.
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S. Jähnichen
"It's a pretty important thing that they've done," said synthetic biologist linkurl:Jason Chin; of the Medical Research Council Laboratory of Molecular Biology in Cambridge, UK. Plus, after the previous controversy-ridden setback, the new findings might well be a welcome step forward for the field. "Any method where you install that first sugar [onto a protein] would be a big advance," Chin said. The study, linkurl:published online today (February 28) in Nature Chemical Biology,; describes the addition of sugars to proteins, a process known as glycosylation. Glycosylation is one of the most common posttranslational modifications in eukaryotes, known to affect protein...
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