Contents Id and angio Testosterone boost to favored offspring More dopamine To B or not to B Mice that know when to say when Viral conquest Unraveling helicase Done in by a sucker ID AND ANGIO When Robert Benezra of the Memorial Sloan-Kettering Cancer Center, New York, and colleagues knocked out two proteins that inhibit transcription factors in mice, they expected to see premature neural differentiation. In addition, however, they noticed that the absence of those two proteins, Id1 and Id3, disrupted angiogenesis in the central nervous system (D. Lyden et al., "Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumor xenografts," Nature, 401:670-7, Oct. 14, 1999). "That was a surprise to us." Benezra notes that the two proteins could prove to be important anticancer targets because Id knockouts in tumor xenograft models showed "absolutely zero potential" to grow breast and lymphoma tumors. "We do already have ...
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Contents Id and angio Testosterone boost to favored offspring More dopamine To B or not to B Mice that know when to say when Viral conquest Unraveling helicase Done in by a sucker ID AND ANGIO When Robert Benezra of the Memorial Sloan-Kettering Cancer Center, New York, and colleagues knocked out two proteins that inhibit transcription factors in mice, they expected to see premature neural differentiation. In addition, however, they noticed that the absence of those two proteins, Id1 and Id3, di
Written byPaul Smaglik
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