Opening a Can of Worms

A father’s determination to help his son resulted in an experimental treatment for autism that uses roundworms to modulate inflammatory immune responses. Can the worms be used to treat other diseases?

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In 2005 the Johnson family was at its breaking point. Lawrence, the family’s 13-year-old son, was diagnosed with autism at age two and a half, and his parents had valiantly coped with his illness for the ensuing decade.

Throughout his childhood, Lawrence’s disorder progressed along the typical path: he would not engage in pretend play like other children, he repeated himself incessantly, his interests were very restricted, and he was frequently agitated and anxious.

By his teenage years, Lawrence had veered into the dangerous realm of self abuse. He smashed his head against the wall dozens of times a day. He bit himself until he bled. He gouged at his eyes and tore at his face. A normal school experience was virtually impossible. He couldn’t walk a single block from the family’s Brooklyn brownstone without kicking and screaming when a traffic light changed at the wrong moment or streets were ...

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Meet the Author

  • Bob Grant

    From 2017 to 2022, Bob Grant was Editor in Chief of The Scientist, where he started in 2007 as a Staff Writer.

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