Our own 60 mutations

New estimates of human mutation suggest that each of us harbor approximately 60 novel genetic mutations.

| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00
Share

FLICKR, GRAHAM RICHARDSON

Researchers estimate that each individual human inherits some 60 genetic mutations not found in either parent—an average of one mutation for every 100 million nucleotides. Previous estimates of human mutation rate have been based on averages of many individuals, but this new count is the first direct measure of the genetic novelties each child brings into the world. The researchers counted the number of new mutations found in two children whose genomes (as well as their parents' genomes) were sequenced as part of the 1000 Genomes Project. The results, published online this week in Nature Genetics, showed that the sources of these mutations vary: while one child derived 92 percent of his mutations from his father's sperm, the other inherited 64 percent from his mother's ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Keywords

Meet the Author

  • Jef Akst

    Jef Akst was managing editor of The Scientist, where she started as an intern in 2009 after receiving a master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses.
Share
A greyscale image of cells dividing.
March 2025, Issue 1

How Do Embryos Know How Fast to Develop

In mammals, intracellular clocks begin to tick within days of fertilization.

View this Issue
iStock: Ifongdesign

The Advent of Automated and AI-Driven Benchwork

sampled
Discover the history, mechanics, and potential of PCR.

Become a PCR Pro

Integra Logo
3D rendered cross section of influenza viruses, showing surface proteins on the outside and single stranded RNA inside the virus

Genetic Insights Break Infectious Pathogen Barriers

Thermo Fisher Logo
A photo of sample storage boxes in an ultra-low temperature freezer.

Navigating Cold Storage Solutions

PHCbi logo 

Products

Sapio Sciences

Sapio Sciences Makes AI-Native Drug Discovery Seamless with NVIDIA BioNeMo

DeNovix Logo

New DeNovix Helium Nano Volume Spectrophotometer

Olink Logo

Olink® Reveal: Accessible NGS-based proteomics for every lab

Olink logo
Zymo Logo

Zymo Research Launches the Quick-16S™ Full-Length Library Prep Kit