mutations

A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.

The genes are involved in pacing the development of inhibitory and excitatory neurons. An imbalance in these two types of signaling is thought to play a role in autism.

He famously identified the genetic mutation that causes the condition in 1991.

The SARS-CoV-2 variant was first detected in January, but its rising prevalence and potential resistance to vaccines has garnered it special attention from the World Health Organization.

Genetic, transcriptomic, and epigenetic data reveal molecular mechanisms tying these disorders to each other and to immune disfunction.

The FDA pauses the research program on a lentivirus-based treatment for a rare neurological condition after a patient developed a bone marrow disorder that could presage leukemia.

The genomes of the children of people exposed to fallout from the Chernobyl nuclear accident appear to carry no trace of the incident.

The P.1 variant, which has also been detected in five US states, could be responsible for cases of reinfection, according to a preprint.

Cells found in different branches of a tree have different patterns of DNA methylation, changes in which accumulate over time.

Researchers identify deletions in the N-terminal domain of the spike protein that allow the coronavirus to avoid antibody neutralization and that may contribute to the emergence of new variants.

A preprint casts doubt on vaccine effectiveness in light of certain mutations in the 501Y.V2 variant that emerged from South Africa.

Whole-genome sequencing reveals a wide range of UV-induced DNA changes in human skin cells, and lighter skin collects more mutations, sometimes to “sky high” levels.

DNA replication errors during cell division cause monozygotic twins to diverge from each other even during the earliest stages of development, a new study finds.

Three studies identify unintended consequences of gene editing in human embryos, including large deletions and reshuffling of DNA.

The small number of genetic differences between the original strain of the novel coronavirus from Wuhan and those currently circulating in the US population indicates that a vaccine may likely offer lasting immunity.

Researchers determined that the incidence of new genetic mutations is comparable in people of different ancestries, but lower in Amish people.

Colorectal tumor cells limit their DNA repair in response to a targeted therapy, giving them a greater chance to develop resistance to the drug.

Autophagy may keep cell division in check to help protect against cancer-causing DNA damage.