mutations
Advisors to FDA Recommend Approval of Gene Therapy for Blindness
Advisors to FDA Recommend Approval of Gene Therapy for Blindness
Jef Akst | Oct 12, 2017
Spark Therapeutics’s Luxturna would be the first approved therapy in the U.S. that replaces or repairs a defective gene inherited from one’s parents.
Icelanders’ Genomes Hint at Origins of Genetic Diversity
Icelanders’ Genomes Hint at Origins of Genetic Diversity
Ashley Yeager | Sep 20, 2017
An analysis of 14,000 genomes reveals regions where new mutations are more likely to develop.
Scientists Edit Viable Human Embryos in U.S.
Scientists Edit Viable Human Embryos in U.S.
Kerry Grens | Jul 27, 2017
The embryos, whose genes were altered by CRISPR, were not intended for implantation. 
Massive RNAi Screens Probe for Genes Important to Cancer
Massive RNAi Screens Probe for Genes Important to Cancer
Kerry Grens | Jul 27, 2017
Two freely available databases include data on hundreds of human cancer cell lines. 
Most of Human Genome Nonfunctional: Study
Most of Human Genome Nonfunctional: Study
Kerry Grens | Jul 17, 2017
An estimate derived from fertility rates concludes that at least 75 percent of our DNA has no critical utility.
First Genetic Screen of Pigs Using ENU
First Genetic Screen of Pigs Using ENU
Ashley Yeager | Jul 14, 2017
Using the mutagenic chemical N-ethyl-N-nitrosourea, researchers confirm the role of a gene in a piglet deformity and identify potential models for human diseases. 
234-Year-Old Tree Has Impressively Stable Genome
234-Year-Old Tree Has Impressively Stable Genome
Jef Akst | Jun 20, 2017
Genomic analysis of an oak tree that lived during Napoleon’s time supports the idea that plants somehow avoid the accumulation of mutations in their stem cells.
More than 18,000 Genomic Records from Cancer Patients Available
More than 18,000 Genomic Records from Cancer Patients Available
Kerry Grens | Jun 1, 2017
The publicly available database found nearly a third of samples included mutations targeted by either approved drugs or therapies in clinical trials. 
Cell Lines Gain Cancer-Related Mutations
Cell Lines Gain Cancer-Related Mutations
Kerry Grens | Apr 27, 2017
A screen of human embryonic stem cell lines finds several that accumulated changes in the gene TP53, including aberrations commonly seen in cancer.
CRISPR-Based Nucleic Acid Test Debuts
CRISPR-Based Nucleic Acid Test Debuts
Diana Kwon | Apr 13, 2017
SHERLOCK combines CRISPR-Cas13a with isothermal RNA amplification to detect RNA and DNA with single-base specificity.