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DNA Replication Errors Contribute to Cancer Risk
Anna Azvolinsky | Mar 23, 2017
A follow-up study confirms that random mutations acquired during normal stem cell division likely play a major role in cancer incidence.
Mutation vs. Mutation
Kerry Grens | Nov 3, 2016
Yeast study finds many instances—often among related genes—in which a mutation in one gene cancels the negative effects of a mutation in another.
Largest Human Genetic Variation Repository Yet
Anna Azvolinsky | Aug 17, 2016
An open-access catalog of tens of thousands of human exome sequences highlights the power of a very large genomic dataset in pinpointing genes linked to rare diseases.
“Redhead” Gene Variant Boosts Melanoma Risk
Tanya Lewis | Jul 12, 2016
People without red hair who possess the variant are also more likely to develop this form of skin cancer, researchers report.
Immune Defect Detected in Knockout Mice
Tanya Lewis | May 20, 2016
Researchers have identified a mutation in a commonly used commercial mouse strain that could impact experimental results.
Advances in Genome Editing
Catherine Offord | Apr 20, 2016
Researchers develop a CRISPR-based technique that efficiently corrects point mutations without cleaving DNA.
Tanya Lewis | Apr 11, 2016
An analysis of the genomes of nearly 600,000 healthy individuals reveals a handful of people who appear resistant to certain genetic disorders.
A Tree Takes Root
Ashley P. Taylor | Apr 1, 2016
Four apparently unrelated individuals share a common ancestor from whom they inherited a rare mutation that predisposed them to the cancer they share.
Pulling It All Together
Kate Yandell | Apr 1, 2016
Systems-biology approaches offer new strategies for finding hard-to-identify drug targets for cancer.
Mutations Not Tied to Metastasis
Kerry Grens | Feb 25, 2016
Clinical cases link immune changes to a cancer’s spread through the body, but find no role for so-called “driver” mutations.