People: Russian Scientist Takes Sabbatical With U.S. Biotech

Russian Scientist Takes A Sabbatical With U.S. Biotech Two Researchers From France, Australia Receive U.S. Nobel "Predictor" Award Obituary - Bernard D. Davis Vladimir A. Efimov, head of the Laboratory of Gene Engineering at the Shemyakin Institute of Bioorganic Chemistry, Moscow, is spending a year's sabbatical as a visiting scientist at Triplex Pharmaceutical Corp. in The Woodlands, Texas. The four-year-old biotechnology

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Russian Scientist Takes A Sabbatical With U.S. Biotech
Two Researchers From France, Australia Receive U.S. Nobel "Predictor" Award

Obituary - Bernard D. Davis

Vladimir A. Efimov, head of the Laboratory of Gene Engineering at the Shemyakin Institute of Bioorganic Chemistry, Moscow, is spending a year's sabbatical as a visiting scientist at Triplex Pharmaceutical Corp. in The Woodlands, Texas.

The four-year-old biotechnology company is working on producing novel drugs to inhibit the onset of certain viral disease and cancers. Its approach is based on using oligonucleotides--short sequences of DNA building blocks-- that form triple helical complexes with specific regions of DNA, thereby preventing the genes from expressing themselves. Efimov was invited to help in designing the specific oligonucleotides.

"This approach is very promising for the future of pharmaceuticals," says Efimov, whose expertise is in nucleic acid chemistry and recombinant DNA technology. "We are trying to produce oligonucleotides that can bind tightly ...

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