Protein Binding

Edited by: Thomas W. Durso S.D. Rosen, C.R. Bertozzi, "The selectins and their ligands," Current Opinion in Cell Biology, 6:663-73, 1994. (Cited in more than 60 publications through April 1996) Comments by Steven D. Rosen, University of California, San Francisco The selectins are a trio of related proteins involved in leukocyte-endothelium interactions, affecting the ability of leukocytes-that is, white blood cells-to interact with blood vessel walls. THREEPEAT: The selectins are a threesome

Written byCarolyn Bertozzi

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Edited by: Thomas W. Durso
S.D. Rosen, C.R. Bertozzi, "The selectins and their ligands," Current Opinion in Cell Biology, 6:663-73, 1994. (Cited in more than 60 publications through April 1996) Comments by Steven D. Rosen, University of California, San Francisco

The selectins are a trio of related proteins involved in leukocyte-endothelium interactions, affecting the ability of leukocytes-that is, white blood cells-to interact with blood vessel walls.

THREEPEAT: The selectins are a threesome of related proteins, says UC-San Francisco's Steven Rosen.

First identified at the molecular level in 1989 (L.M. Stoolman, Cell, 56:907-10, 1989), selectins are the topic of this review paper by Steven D. Rosen, a professor in the department of anatomy and program in immunology at the University of California, San Francisco, and Carolyn R. Bertozzi, a former postdoc in Rosen's lab and now an assistant professor of chemistry at the University of California, Berkeley.

The paper summarizes the ...

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