Protein Degradation

Edited by: Thomas W. Durso and Karen Young Kreeger M. Hochstrasser, "Ubiquitin, proteasomes, and the regulation of intracellular protein degradation," Current Opinion in Cell Biology, 7:215-23, 1995. (Cited in nearly 120 publications as of February 1997) Comments by Mark Hochstrasser, department of biochemistry and molecular biology, University of Chicago. IN ON THE GROUND FLOOR: This review summarized the state of the field when many people were just starting to get interested in the ubiquit

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Edited by: Thomas W. Durso and Karen Young Kreeger
M. Hochstrasser, "Ubiquitin, proteasomes, and the regulation of intracellular protein degradation," Current Opinion in Cell Biology, 7:215-23, 1995. (Cited in nearly 120 publications as of February 1997)

Comments by Mark Hochstrasser, department of biochemistry and molecular biology, University of Chicago.

IN ON THE GROUND FLOOR: This review summarized the state of the field when many people were just starting to get interested in the ubiquitin pathway, says University of Chicago's Mark Hochstrasser.

This review article by Mark Hochstrasser, an associate professor of biochemistry and molecular biology at the University of Chicago, presents a summary of research on the ubiquitin/proteasome pathway and its extensive physiological significance. The proteasome-part of the internal cellular machinery-breaks down specific cellular proteins. Ubiquitin is a protein that attaches to other proteins to earmark them for degradation by helping the proteins stick to the proteasome.

Hochstrasser notes that ...

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